Tert-butyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamate → {5-[4'-(1-Methanesulfonylaminocarbonyl-cyclopropyl)-biphenyl-4-yl]-3-methyl-isoxazol-4-yl}-carbamic acid tert-butyl ester

HRID 1183534Notes

Reaction equation

HRID 1183534 reaction equation
[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[C:9]([CH3:20])=[N:10][O:11][C:12]=1[C:13]1[CH:18]=[CH:17][C:16](Br)=[CH:15][CH:14]=1)([CH3:4])([CH3:3])[CH3:2].CC1(C)C(C)(C)OB([C:30]2[CH:35]=[CH:34][C:33]([C:36]3([C:39]([NH:41][S:42]([CH3:45])(=[O:44])=[O:43])=[O:40])[CH2:38][CH2:37]3)=[CH:32][CH:31]=2)O1>>[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[C:9]([CH3:20])=[N:10][O:11][C:12]=1[C:13]1[CH:18]=[CH:17][C:16]([C:30]2[CH:31]=[CH:32][C:33]([C:36]3([C:39]([NH:41][S:42]([CH3:45])(=[O:44])=[O:43])=[O:40])[CH2:38][CH2:37]3)=[CH:34][CH:35]=2)=[CH:15][CH:14]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 66577242Tert-butyl (5-(4-bromophenyl)-3-methylisoxazol-4-yl)carbamateHCID 66577823N-{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarbonyl}-methanesulfonamide

Product 1

HCID 66577855{5-[4'-(1-Methanesulfonylaminocarbonyl-cyclopropyl)-biphenyl-4-yl]-3-methyl-isoxazol-4-yl}-carbamic acid tert-butyl ester

Procedure

Prepared according to the procedure described in Example 166, Step 3, using [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-carbamic acid tert-butyl ester and N-{1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-cyclopropanecarbonyl}-methanesulfonamide.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-bae6b3bd1757431aa8164d6c62b47ae6
Source dataset
uspto-grants-2014_03
Patent number
US08664220B2

Reaction notes

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