反应详情

温度

50 °C

1.0 g 5-ethynyl-2-methylpyridine (8.5 mmol) was loaded into a flask provided with magnetic anchor and was dissolved in 10 mL of a 1:4 toluene/sulfuric acid mixture (0.29 mmol). The resulting solution was heated to 50° C. overnight, then after quenching to room temperature, the solution was basified by the addition of NaHCO3, then it was extracted with AcOEt (3×20 mL) and finally, anhydrified on anhydrous MgSO4. The organic phase was then concentrated under vacuum yielding 1.06 g product, equal to a molar yield of 91% as a yellow oil.

1. customprovided with magnetic anchor
2. customafter quenching to room temperature
3. additionthe solution was basified by the addition of NaHCO3
4. extractionit was extracted with AcOEt (3×20 mL)
5. concentrationThe organic phase was then concentrated under vacuum