Potassium Carbonate → HCID 24813854, compound

Participants

Reaction Steps

K2CO3 (1.1 g, 8.0 mmol, 10 eq.) is added to a solution of compound 10 (280 mg, 810 μmol) in dry DMF (12 mL). The reaction is stirred for 15 minutes and ethyl bromobutanoate (175 μL, 1.22 mmol, 1.5 eq.) is slowly added. The mixture is stirred for 24 hours at room temperature and then concentrated. The residue is taken up in dichloromethane and water. The two-phase mixture is allowed to separate by settling, and the organic phase is washed several times with water. After drying and concentrating, a solid is obtained which is purified by chromatography (elution with a methanol gradient from 0 to 1% in dichloromethane) to give 275 mg (530 μmol) of compound 11 in the form of an orange powder (yield: 75%).

Provenance & Evidence