Hydrochloric Acid → S 38093-2

Participants

Reaction Steps

14.69 kg of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy}benzamide and 122 L of water are introduced into a reactor. A solution of 6.81 kg of 37% hydrochloric acid in 11.54 L of water is also prepared. 13.75 kg of this acid solution are added to the reactor. The mixture is stirred for 1 hour at ambient temperature, and then for 1 hour 30 minutes at 60° C. The suspension is filtered in the hot state and the filter is then rinsed with water. A solvent change is then carried out on the filtrate, keeping the volume constant, in order to obtain an isopropanol/water ratio of 9/1. The product is isolated at 0° C. and the precipitate obtained is washed with isopropanol. The title product is finally obtained in a yield of 89% and with a chemical purity greater than 99%.

Provenance & Evidence