Water → HCID 66679455, compound

Participants

Reaction Steps

To a solution of 6.35 g (15.4 mmol) of (3-aminopropyl)-(4-benzyloxycarbonyl-aminobutyl)-carbamic acid benzyl ester (Synth. Commun. 2005, 35, 1085) in 200 mL of acetonitrile, and 2.6 mL (1.86 g, 15.4 mmol) of triethylamine, there are introduced, with stirring, at ambient temperature, 1.70 mL (2.56 g, 15.4 mmol) of ethyl bromoacetate. Stirring is maintained for 4 hours. The reaction mixture is poured into water and extracted with ethyl acetate. The organic phases are separated off and then dried over sodium sulfate, filtered and evaporated. 7.7 g of an oil are obtained, which is used directly in the following step.

Provenance & Evidence