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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1183824Generated: November 4, 2026

6-Methyl-5-nitroisoquinoline → 6-[(6-Chloropyridin-3-yl)methyl]-3-[(1S,2S)-2-hydroxycyclohexyl]pyrido[2,3-h]quinazolin-4(3H)-one

https://huagongshe.com/reaction/1183824

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-Methyl-5-nitroisoquinolineHCID 25059050—
Reactant6-[(6-Chloropyridin-3-yl)methyl]-3-[(1S,2S)-2-hydroxycyclohexyl]pyrido[3,4-h]quinazolin-4(3H)-oneHCID 53261228—
Product6-[(6-Chloropyridin-3-yl)methyl]-3-[(1S,2S)-2-hydroxycyclohexyl]pyrido[2,3-h]quinazolin-4(3H)-oneHCID 53260770—

Reaction Steps

6-[(6-Chloropyridin-3-yl)methyl]-3-[(1S,2S)-2-hydroxycyclohexyl]pyrido[2,3-h]quinazolin-4(3H)-one was prepared by the procedure described for the synthesis of 6-[(6-chloropyridin-3-yl)methyl]-3-[(1S,2S)-2-hydroxycyclohexyl]pyrido[3,4-h]quinazolin-4(3H)-one in Example 1, substituting 6-methyl-5-nitroquinoline for 6-methyl-5-nitroisoquinoline.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08664387B2
Source datasetuspto-grants-2014_03
ORD IDord-7136c9b4d4804138bbd14a2b83d6950d
Source noteuspto-grants-2014_03