HCID 69925537, compound → HCID 68379942, compound

HRID 1183829Notes

Reaction equation

HRID 1183829 reaction equation
[OH:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@@H:3]1[N:8]1[C:17](=[O:18])[C:16]2[C:11](=[C:12]3[CH:32]=[CH:31][N:30]=[CH:29][C:13]3=[C:14]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([CH:26]([OH:28])[CH3:27])=[CH:22][CH:21]=3)[CH:15]=2)[N:10]=[CH:9]1.[CH3:33][Mg]Br>>[OH:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@@H:3]1[N:8]1[C:17](=[O:18])[C:16]2[C:11](=[C:12]3[CH:32]=[CH:31][N:30]=[CH:29][C:13]3=[C:14]([CH2:19][C:20]3[CH:25]=[CH:24][C:23]([CH:26]([OH:28])[CH:27]=[CH2:33])=[CH:22][CH:21]=3)[CH:15]=2)[N:10]=[CH:9]1

Participants

3

Reactant 2

HCID 69925537HCID 69925537, compoundHCID 178418573HCID 178418573, compound

Product 1

HCID 68379942HCID 68379942, compound

Procedure

3-[(1S,2S)-2-Hydroxycyclohexyl]-6-[4-(1-hydroxyprop-2-en-1-yl)benzyl]pyrido[3,4-h]quinazolin-4(3H)-one was prepared by the procedure described for the synthesis of 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[4-(1-hydroxyethyl)benzyl]pyrido[3,4-h]quinazolin-4(3H)-one in Example 11, substituting vinylmagnesium bromide for methylmagnesium bromide.

Sources & evidence

ORD record
ord-2d8965dbe0a441449f3bbbb0d98b4d77
Source dataset
uspto-grants-2014_03
Patent number
US08664387B2

Reaction notes

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