Dichloromethane → Chlorobutyl ferrocene

Participants

Reaction Steps

A cold solution of freshly distilled trifluoroacetic acid (5 ml) was added to a solution of the ferrocene derivative, 1-Oxo-4-chlorobutylferrocene I, (5 g, 17.2 mmole) in dry dichloromethane (15 ml) at 0° C. Sodium borohydride (0.78 g) was added to the reaction mixture at 0° C. and the reaction mixture was stirred overnight at this temperature. After completion of the reaction as indicated from TLC, the reaction was quenched by adding water (50 ml) and the mixture was extracted with dichloromethane (2×25 ml).

Provenance & Evidence