Hydrogen chloride-ethyl acetate → HCID 178495052, compound

HRID 1184129Notes

Reaction equation

HRID 1184129 reaction equation
[F:1][C:2]1[C:7]2[N:8]([CH2:36][CH2:37][CH2:38][CH2:39][O:40][CH3:41])[C:9]([C:11]([N:13]([CH2:32][CH:33]([CH3:35])[CH3:34])[C@H:14]3[CH2:19][C@@H:18]([C:20]4[NH:24][CH:23]=[N:22][N:21]=4)[CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]3)=[O:12])=[N:10][C:6]=2[CH:5]=[CH:4][CH:3]=1.C(OCC)(=O)C.[ClH:48]>>[ClH:48].[ClH:48].[F:1][C:2]1[C:7]2[N:8]([CH2:36][CH2:37][CH2:38][CH2:39][O:40][CH3:41])[C:9]([C:11]([N:13]([CH2:32][CH:33]([CH3:34])[CH3:35])[C@H:14]3[CH2:19][C@@H:18]([C:20]4[NH:24][CH:23]=[N:22][N:21]=4)[CH2:17][NH:16][CH2:15]3)=[O:12])=[N:10][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 178495050HCID 178495050, compound

Product 1

HCID 178495052HCID 178495052, compound

Procedure

tert-Butyl (3S,5R)-3-{{{7-fluoro-1-(4-methoxybutyl)-1H-benzimidazol-2-yl}carbonyl}(2-methylpropyl)amino}-5-(4H-1,2,4-triazol-3-yl)piperidine-1-carboxylate (130 mg) was dissolved in 2M hydrogen chloride-ethyl acetate (3 ml), and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated to give the object product (91 mg).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-78927c3665b54b8688bb4272963ec9a3
Source dataset
uspto-grants-2014_03
Patent number
US08664380B2

Reaction notes

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