Hydrogen chloride-ethyl acetate → HCID 67321003, compound

HRID 1184142Notes

Reaction equation

HRID 1184142 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[N:10]=[C:9]([C:11]([N:13]([CH2:35][CH:36]([CH3:38])[CH3:37])[C@H:14]3[CH2:19][C@@H:18]([C:20]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[O:21])[CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]3)=[O:12])[N:8]([CH2:39][CH2:40][CH2:41][CH2:42][O:43][CH3:44])[C:7]=2[CH:45]=1.C(OCC)(=O)C.[ClH:52]>>[ClH:52].[ClH:52].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[N:10]=[C:9]([C:11]([N:13]([CH2:35][CH:36]([CH3:38])[CH3:37])[C@H:14]3[CH2:19][C@@H:18]([C:20]([N:22]4[CH2:23][CH2:24][O:25][CH2:26][CH2:27]4)=[O:21])[CH2:17][NH:16][CH2:15]3)=[O:12])[N:8]([CH2:39][CH2:40][CH2:41][CH2:42][O:43][CH3:44])[C:7]=2[CH:45]=1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 58355678HCID 58355678, compound

Product 1

HCID 67321003HCID 67321003, compound

Procedure

tert-Butyl (3S,5R)-3-{{{6-methoxy-1-(4-methoxybutyl)-1H-benzimidazol-2-yl}carbonyl}(2-methylpropyl)amino}-5-(morpholin-4-ylcarbonyl)piperidine-1-carboxylate (82 mg) was dissolved in 2M hydrogen chloride-ethyl acetate (3 ml), and the mixture was stirred at room temperature for 1 hr and concentrated to give the object product (78 mg).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-925ccc807b30465481df2f5384dada15
Source dataset
uspto-grants-2014_03
Patent number
US08664380B2

Reaction notes

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