HCID 23498110, compound → HCID 2304284, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of diethyl 2,2-dimethylpropanimidamide m hydrochloride (1.36 g) and (ethoxymethylene)malonate (2.16 g) in ethanol (100 ml) was added 20% sodium ethoxide-ethanol solution (6.8 g) under ice-cooling, and the mixture was stirred at 80° C. for 5 hr. The reaction mixture was concentrated under reduced pressure, 1M hydrochloric acid (10 ml) was added under ice-cooling, and the mixture was extracted with ethyl acetate. The extract was concentrated under reduced pressure, hexane was added to the residue, and the precipitate was collected by filtration to give the object product(1.65 g) as a powder.

Provenance & Evidence