Diphosgene → HCID 86690139, compound

Participants

Reaction Steps

Diphosgene (0.445 ml, 3.69 mmol) was added dropwise to a stirred solution of N′-(2,2,7-trifluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)pivalohydrazide (1311 mg, 3.69 mmol) in dry toluene (30 ml) at room temperature under nitrogen. The resulting mixture was stirred at reflux for 4 hours. It was then cooled to room temperature and evaporated in vacuo to yield 1.7 g of crude product. Trituration of this with diisopropyl ether afforded 990 mg of the title compound as a white powder (purity>95%).

Provenance & Evidence