Propylamine → HCID 86690140, compound

Participants

Reaction Steps

Propan-1-amine (0.937 ml, 11.74 mmol) was added to a stirred solution of 2,2,7-trifluoro-6-isothiocyanato-4-(prop-2-ynyl)-2H-benzo[b][1,4]oxazin-3(4H)-one (the product of Step 4.1 above, 1.0 g, 3.35 mmol) in dichloromethane (10 ml) at room temperature under nitrogen. The resulting mixture was stirred at room temperature for 1 hour, by which time TLC analysis indicated that the reaction was complete. The reaction mixture was evaporated in vacuo to yield 1.3 g of the desired product (purity>95%), which was used without further purification in the next step.

Provenance & Evidence