反应详情

To a solution of 5b (1.1 g, 4.89 mmol) in ethanol (20 mL) an ammonia solution is added (32%, 5 mL). The solution obtained is agitated 14 h at ambient temperature then 10 mL of ammonia are added and the mixture agitated for 48 h. The solution is concentrated under reduced pressure and the residue is dissolved in petroleum ether. The formed precipitate is filtered, washed in petroleum ether and vacuum dried (0.75 g, 78%).

1. customThe solution obtained
2. stirringthe mixture agitated for 48 h
3. concentrationThe solution is concentrated under reduced pressure
4. dissolutionthe residue is dissolved in petroleum ether
5. filtrationThe formed precipitate is filtered
6. washwashed in petroleum ether
7. customvacuum dried (0.75 g, 78%)