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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1184354Generated: October 27, 2026

3,4-Dihydro-8-fluoro-2H-1,4-benzoxazine-2-carboxamide → Dihydro-8-methyl-2H-1,4-benzoxazine-2-carboxamide

https://huagongshe.com/reaction/1184354

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3,4-Dihydro-8-fluoro-2H-1,4-benzoxazine-2-carboxamideHCID 67480486—
Reactant3,4-dihydro-8-methyl-2H-1,4-benzoxazine 2-ethyl carboxylateHCID 86664801—
ProductDihydro-8-methyl-2H-1,4-benzoxazine-2-carboxamideHCID 67497427—

Reaction Steps

This compound is obtained using the same experimental conditions as those used for the synthesis of intermediate (4b) but replacing 3,4-dihydro-8-fluoro-2H-1,4-benzoxazine-2-ethyl carboxylate (5b) with 3,4-dihydro-8-methyl-2H-1,4-benzoxazine-2-ethyl carboxylate (5c), [220120-58-1]. The title compound of formula (4c) is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08669250B2
Source datasetuspto-grants-2014_03
ORD IDord-e0865f657e7f48bc87856689f92ea58b
Source noteuspto-grants-2014_03