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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1184359Generated: October 25, 2026

3-Amino-2-hydroxybenzonitrile → Dihydro-8-cyano-2H-1,4-benzoxazine-2-methanamine

https://huagongshe.com/reaction/1184359

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Amino-2-hydroxybenzonitrileHCID 12468681—
ReactantDihydro-8-fluoro-2H-1,4-benzoxazine-2-methanamineHCID 67497870—
ProductDihydro-8-cyano-2H-1,4-benzoxazine-2-methanamineHCID 67497003—

Reaction Steps

This compound is obtained using the same reaction sequence and the same experimental conditions as those used for the synthesis of intermediate 2b but replacing 2-amino-6-fluorophenol with 2-amino-6-cyanophenol. The title compound of formula (2f) is obtained.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08669250B2
Source datasetuspto-grants-2014_03
ORD IDord-f59af44eaafe4455970022d0d05fc476
Source noteuspto-grants-2014_03