HCID 70348174, compound → HCID 68106252, compound

HRID 1184363Notes

Reaction equation

HRID 1184363 reaction equation
[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([S:7]([NH:10]C(=O)OCC2C=CC=CC=2)(=[O:9])=[O:8])[CH2:3]1>[C].[Pd].CO>[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([S:7]([NH2:10])(=[O:9])=[O:8])[CH2:3]1

Participants

4

Reactant 1

HCID 70348174HCID 70348174, compound

Product 1

HCID 68106252HCID 68106252, compoundYield 99.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Benzyl [(3-hydroxypyrrolidin-1-yl)sulfonyl]carbamate (2.55 g) was added to MeOH, and subsequently, 10% palladium carbon (657 mg, 55% wet) was added thereto, followed by stirring at a normal temperature/a normal pressure for about 3 hours under a hydrogen atmosphere. The catalyst was collected by filtration through Celite, and the filtrate was concentrated under reduced pressure to obtain 3-hydroxypyrrolidin-1-sulfonamide (1.4 g) as a colorless oily substance.

Workup

  1. filtrationThe catalyst was collected by filtration through Celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-f15d022161e3485c9eccc1958a663c74
Source dataset
uspto-grants-2014_03
Patent number
US08669246B2

Reaction notes

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