O-Methylhydroxylamine hydrochloride → HCID 57378999, compound

Participants

Reaction Steps

To a solution under of 100 mg of 5-(4-chloro-phenyl)-6-cyclopropylmethoxy-N-((S)-2-oxo-cyclohexyl)-nicotinamide in 1 ml methanol was added 105 mg O-methylhydroxylamine hydrochloride and the mixture was stirred at room temperature for 18 h. The reaction mixture was partitioned between water and ethyl acetate. The phases were separated and the organic phase was purified by chromatography on silica gel using a gradient of heptane:ethyl acetate=95:5 to 50:50 to yield 0.039 g of the title compound as white foam. MS (EI): 402.3 (M+H).

Provenance & Evidence