Triacetoxyperiodinane → HCID 67970698, compound

Participants

Reaction Steps

To a solution of 1.651 g 5-(4-chloro-phenyl)-6-cyclopropylmethoxy-N-((1S,2R)-2-hydroxy-cyclohexyl)-nicotinamide in 25 ml methylene chloride, was added 2.62 g Dess-Martin periodinane as 15% solution in dichloromethane. The reaction mixture was stirred at room temperature for 18 h. The solvent was evaporated and the residue was purified by chromatography on silica gel using a gradient of heptane:ethyl acetate=95:5 to 40:60 to yield 1.46 g of the title compound as white foam. MS (EI): 399.1 (M+H).

Provenance & Evidence