Hydroxylamine → HCID 57377352, compound

Participants

Reaction Steps

To a solution of 0.100 g N-(2-cyclopropyl-2-oxo-ethyl)-5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide in 1.0 ml methanol was added 0.052 g of 50% aqueous hydroxylamine and the mixture was kept at ambient temperature for 18 h. The solvent was evaporated and the residue was purified by chromatography on silica gel with a gradient of heptane:ethyl acetate=9:1 to 1:1 to yield 0.093 g of the title compound as white crystals. MS (EI): 462.0599 (M+H).

Provenance & Evidence