HCID 86667098, compound → HCID 86667097, compound

Participants

Reaction Steps

A suspension of 3.00 g 2-[5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-4-(2,2,2-trifluoro-acetyl)-4H-oxazol-5-one in 15 ml water and 15 ml dioxan was heated to reflux for 1 h. The resulting slightly turbid solution was partitioned between water and ethyl acetate. The phases were separated and the organic phase was purified by chromatography on silica gel with heptane:ethyl acetate=9:1 to 1:1. The product fractions were concentrated and the residue was taken up in dichloromethane whereby crystallization occurred. The solid was collected by filtration and washed with little dichloromethane to yield 1.60 g of the title compound as white solid. m.p.: 122-124° C. MS (EI): 474 (M+).

Provenance & Evidence