3,4-Dichlorobenzeneboronic acid → HCID 67286406, compound

HRID 1184397Notes

Reaction equation

HRID 1184397 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:22])([F:21])[F:20])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([OH:15])=[O:14])=[CH:4][CH:3]=1.[Cl:23]C1C=C(B(O)O)C=CC=1Cl>>[Cl:23][C:7]1[CH:6]=[C:5]([C:8]2[C:9]([O:17][CH2:18][C:19]([F:22])([F:20])[F:21])=[N:10][CH:11]=[C:12]([CH:16]=2)[C:13]([OH:15])=[O:14])[CH:4]=[CH:3][C:2]=1[Cl:1]

Participants

3

Reactant 2

HCID 27343303,4-Dichlorobenzeneboronic acidHCID 666869715-(4-Chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid

Product 1

HCID 67286406HCID 67286406, compound

Procedure

In analogy to 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid (WO 2008/040651) by substituting 4-chlorophenylboronic acid with 3,4-dichlorophenylboronic acid the title compound was obtained as white solid. MS (EI): 365.9 and 364.1 (M−H).

Sources & evidence

ORD record
ord-4e5e4cd186c647e18db9ebfc4a47da14
Source dataset
uspto-grants-2014_03
Patent number
US08669254B2

Reaction notes

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