2,2,2-Trifluoroethanol → 6-Chloro-3-(2,2,2-trifluoroethoxy)pyridazin-4-amine

Participants

Reaction Conditions

Reaction Steps

To a solution of 3.28 g 3,6-dichloro-pyridazin-4-ylamine in 30 ml dimethylsulfoxide and 4.0 g trifluoroethanol was added 1.84 g lithium hydroxide hydrate and 3 ml water and the mixture was heated to 80° C. for 18 h. The reaction mixture was diluted with 100 ml water and stirred at ambient temperature for 2 h. The resulting solid was collected by filtration washed with water and dried to constant weight under high vacuum to yield 3.84 g of the title compound as off white crystals. MS (EI): 228.1 and 230.1 (M+H).

Provenance & Evidence