Sodium hydride → HCID 28413999, compound

Participants

Reaction Steps

To a solution of 1.016 ml cyclopropanemethanol in 10 ml dimethylsulfoxide was added 0.564 g sodium hydride 55% in mineral oil and the mixture was stirred at room temperature for 15 min. The resulting solution was added drop wise to a solution of 2.0 g 3,6-dichloropyridazine in 20 ml dry dimethylsulfoxide at room temperature and stirred at this temperature for 1 h. The reaction mixture was partitioned between water and ethyl acetate, the phases were separated and the organic phase was purified by chromatography on silica gel using a gradient of heptane: ethyl acetate=95:5 to 40:60 to yield 1.88 g of the title compound as white solid. MS (EI): 185.05 (M+H).

Provenance & Evidence