Ethylene Glycol → HCID 68199694, compound

Participants

Reaction Steps

(1R,2R)-2-(o-tolyl)-4-oxo-cyclohexanecarboxylic acid (500 mg, 2.153 mmol) in THF (6.0 ml) was reacted with ethylene glycol (0.600 ml, 10.76 mmol) and p-toluenesulfonic acid (82 mg, 0.431 mmol), and then aged at rt until the reaction was complete. The mixture was poured into water and extracted with EtOAc. The combined organic portions were dried (Na2SO4), filtered and concentrated to afford the title compound. HPLC/MS: 231.0 (M-CO2H+1), Rt=1.04 min (LC-2).

Provenance & Evidence