1,2-Dichloroethane → HCID 86692738, compound

Participants

Reaction Steps

A solution of (1R,2R)-2-(4-bromophenyl)-4-oxo-cyclohexane-carboxylic acid (100 mg, 0.300 mmol), 1-(4-chlorophenyl)-2,2,2-trifluoro-ethanamine (the faster eluting enantiomer on AD-H chiral column using MeOH/SF CO2; 62.8 mg, 0.300 mmol) and HOBT (45.9 mg, 0.300 mmol) in CH2Cl2 (5 mL) was reacted with EDC (115 mg, 0.600 mmol) and DMAP (36.6 mg, 0.300 mmol). The reaction was aged at rt until it was complete. The mixture was concentrated and purified on a silica gel column by eluting with 0-50% EtOAc/hexanes to afford the title compound. HPLC/MS: 488.1/490.0 (M+1); Rt=1.19 min (LC-2).

Provenance & Evidence