Phenol → HCID 86664208, compound

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Reaction Steps

Using 3-chloro-4-hydroxy-5-nitrobenzaldehyde as the phenol and methyl-2-bromopropanoate as the alkylating agent in the general procedure for alkylation of substituted-2-nitrophenols gives a light yellow oil: 1H NMR (DMSO-d6, 400 MHz): δ ppm 9.98 (s, 1H), 8.43 (d, J=1.8 Hz, 1H), 8.35 (d, J=2.0 Hz, 1H), 5.08-5.15 (m, 1H), 3.62 (s, 3H), 1.57 (d, J=6.8 Hz, 3H). ESI-MS: m/z 328.1 (M+H)+.

Provenance & Evidence