Phenol → HCID 86664209, compound

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Reaction Steps

Using 4-hydroxy-3-methyl-5-nitrobenzaldehyde as the phenol and methyl-2-bromopropanoate as the alkylating agent in the general procedure for alkylation of substituted-2-nitrophenols gives a tan solid: 1H NMR (DMSO-d6, 400 MHz): δ ppm 9.97 (s, 1H), 8.29 (d, J=1.5 Hz, 1H), 8.09 (d, J=1.5 Hz, 1 H), 4.82 (q, J=6.8 Hz, 1H), 3.62 (s, 3H), 2.42 (s, 3H), 1.52 (d, J=6.8 Hz, 3H). ESI-MS: m/z 268.1 (M+H)+.

Provenance & Evidence