HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → Methyl 4-(2-methoxy-2-oxoethoxy)-3-nitrobenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Methyl bromoacetate | HCID 60984 | — |
| Reactant | Benzoic acid, 4-hydroxy-3-nitro-, methyl ester | HCID 66835 | — |
| Product | Methyl 4-(2-methoxy-2-oxoethoxy)-3-nitrobenzoate | HCID 17368159 | — |
Reaction Steps
Using methyl 4-hydroxy-3-nitrobenzoate as the phenol and methyl 2-bromoacetate as the alkylating agent in the general procedure for alkylation of substituted-2-nitrophenols gives a light yellow solid: 1H NMR (DMSO-d6, 400 MHz): δ ppm 8.39 (d, J=2.0 Hz, 1H), 8.15 (dd, J=8.8, 2.3 Hz, 1H), 7.44 (d, J=8.8 Hz, 1H), 5.16 (s, 2H), 3.87 (s, 3H), 3.71 (s, 3H). ESI-MS: m/z 270.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669249B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-126e50977449480c9852dc7dd79a2a9d |
| Source note | uspto-grants-2014_03 |