HCID 68069072, compound → HCID 67284579, compound

Participants

Reaction Steps

In a 100 mL round bottom flask equipped with a magnetic stir bar was added 183 (67 mg, 0.256 mmol), Pd/C (10% by weight, 5 mg) and EtOH (2 mL). The mixture was stirred under a hydrogen atmosphere (balloon) for 18 h. The reaction was filtered and concentrated in vacuo to give the title compound as a white solid (62 mg, 92% yield): 1H NMR (400 MHz, DMSO-d6) δ ppm 1.15 (t, J=7.07 Hz, 3H) 1.39 (d, J=6.82 Hz, 3H) 2.54 (t, J=7.33 Hz, 2H) 2.75 (t, J=7.45 Hz, 2H) 4.04 (q, J=7.24 Hz, 2H) 4.56-4.63 (m, 1H) 6.71 (d, J=1.77 Hz, 1H) 6.76 (dd, J=8.08, 2.02 Hz, 1H) 6.85 (d, J=8.34 Hz, 1H) 10.61 (s, 1H). ESI-MS: m/z 264.2 (M+H)+.

Provenance & Evidence