Phenol → HCID 86664211, compound

Participants

Reaction Steps

Using 3-fluoro-4-hydroxy-5-nitrobenzaldehyde as the phenol and methyl-2-bromopropanoate as the alkylating agent in the general procedure of alkylation of substituted 2-nitrophenols gives a yellow solid: 1H NMR (400 MHz, DMSO-d6) δ ppm 1.56 (d, J=6.57 Hz, 3H) 3.66 (s, 3H) 5.27 (qd, J=6.78, 1.64 Hz, 1H) 8.10-8.18 (m, 1H) 8.31-8.38 (m, 1H) 9.95 (d, J=2.02 Hz, 1H). ESI-MS: m/z 272.1 (M+H)+.

Provenance & Evidence