Phenol → HCID 86664218, compound

HRID 1184471Notes

Reaction equation

HRID 1184471 reaction equation
[F:1][C:2]1[C:9]([N+:10]([O-:12])=[O:11])=[C:8]([OH:13])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].C1(O)C=CC=CC=1.[CH3:21][O:22][C:23](=[O:27])[CH:24](Br)[CH3:25]>>[F:1][C:2]1[C:9]([N+:10]([O-:12])=[O:11])=[C:8]([CH:7]=[CH:6][C:3]=1[CH:4]=[O:5])[O:13][CH:24]([CH3:25])[C:23]([O:22][CH3:21])=[O:27]

Participants

4

Reactant 3

HCID 996PhenolHCID 95576Methyl 2-bromopropionateHCID 86664219HCID 86664219, compound

Product 1

HCID 86664218HCID 86664218, compound

Procedure

Using 2-fluoro-4-hydroxy-3-nitrobenzaldehyde as the phenol and methyl-2-bromopropanoate as the alkylating agent in the general procedure for alkylation of substituted-2-nitrophenols gives the title compound as a white solid: ESI-MS: m/z 272.1 (M+H)+.

Sources & evidence

ORD record
ord-cb3a51b9e28545029bb35d85dc560ed4
Source dataset
uspto-grants-2014_03
Patent number
US08669249B2

Reaction notes

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