Phenol → HCID 66717225, compound

HRID 1184474Notes

Reaction equation

HRID 1184474 reaction equation
[N:1]1([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([N+:18]([O-:20])=[O:19])[CH:12]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1.C1(O)C=CC=CC=1.[CH3:28][O:29][C:30](=[O:34])[CH:31](Br)[CH3:32]>>[N:1]1([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH:31]([CH3:32])[C:30]([O:29][CH3:28])=[O:34])=[C:13]([N+:18]([O-:20])=[O:19])[CH:12]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[N:2]1

Participants

4

Reactant 3

HCID 996PhenolHCID 95576Methyl 2-bromopropionateHCID 66716781HCID 66716781, compound

Product 1

HCID 66717225HCID 66717225, compound

Procedure

Using 4-((1H-indazol-1-yl)methyl)-2-nitrophenol 345A as the phenol and methyl-2-bromopropanoate as the alkylating agent in the general procedure for alkylation of substituted-2-nitrophenols gives the title compound as a light yellow solid: ESI-MS: m/z 356.2 (M+H)+.

Sources & evidence

ORD record
ord-2cef9a6b67154538870e8e809a1b6b97
Source dataset
uspto-grants-2014_03
Patent number
US08669249B2

Reaction notes

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