N-ethyl-4-(piperazin-1-yl)benzamide → 4-(4-((8-Cyclopropyl-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-ethylbenzamide

Participants

Reaction Steps

Using 346A and N-ethyl-4-(piperazin-1-yl)benzamide 283 in the general procedure for reductive aminations, the title compound was obtained as an off-white solid: 1H NMR (400 MHz, DMSO-d6) δ ppm 0.60-0.70 (m, 2H) 0.88-0.94 (m, 2H) 1.09 (t, J=7.07 Hz, 3H) 1.43 (d, J=6.57 Hz, 3H) 2.04-2.12 (m, 1H) 2.41-2.49 (m, 4H) 3.17-3.29 (m, 6H) 3.36 (s, 2H) 4.64 (q, J=6.82 Hz, 1H) 6.41 (d, J=1.52 Hz, 1H) 6.69 (d, J=1.77 Hz, 1H) 6.92 (m, J=9.09 Hz, 2H) 7.71 (m, J=8.84 Hz, 2H) 8.17 (t, J=5.56 Hz, 1H) 10.55 (s, 1H). ESI-MS: m/z 449.4 (M+H)+.

Provenance & Evidence