N-methyl-4-(piperazin-1-yl)benzamide → 4-(4-((8-Cyclopropyl-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperazin-1-yl)-N-methylbenzamide

Participants

Reaction Steps

Using 346A and N-methyl-4-(piperazin-1-yl)benzamide 282 in the general procedure for reductive aminations, the title compound was obtained as a white solid: 1H NMR (400 MHz, DMSO-d6) δ ppm 0.60-0.71 (m, 2H) 0.87-0.95 (m, 2H) 1.43 (d, J=6.82 Hz, 3H) 2.04-2.12 (m, 1H) 2.40-2.48 (m, 4 H) 2.73 (d, J=4.55 Hz, 3H) 3.18-3.26 (m, 4H) 3.36 (s, 2H) 4.61-4.67 (m, 1H) 6.41 (d, J=1.77 Hz, 1H) 6.69 (d, J=1.77 Hz, 1H) 6.93 (m, 2H) 7.69 (m, 2H) 8.14 (q, J=4.21 Hz, 1H) 10.55 (s, 1H). ESI-MS: m/z 435.4 (M+H)+. mp=256.1-258.6° C.

Provenance & Evidence