反应详情

Using 346A and N-cyclopropyl-4-(piperazin-1-yl)benzamide 284 in the general procedure for reductive aminations, the title compound was obtained as an off-white solid: 1H NMR (400 MHz, DMSO-d6) δ ppm 0.50-0.57 (m, 2H) 0.61-0.70 (m, 4H) 0.89-0.95 (m, 2H) 1.43 (d, J=6.82 Hz, 3H) 2.03-2.12 (m, 1H) 2.40-2.49 (m, 4H) 2.76-2.83 (m, 1H) 3.19-3.26 (m, 4 H) 3.37 (br. s., 2H) 4.64 (q, J=6.82 Hz, 1H) 6.41 (d, J=1.52 Hz, 1H) 6.67-6.73 (m, 1H) 6.91 (m, J=8.84 Hz, 2H) 7.70 (m, J=8.59 Hz, 2H) 8.17 (d, J=3.54 Hz, 1H) 10.57 (s, 1H). ESI-MS: m/z 461.4 (M+H)+. mp=202.5-207.3° C.