反应详情

Using 349A and N-cyclopropyl-4-(piperazin-1-yl)benzamide 284 in the general procedure for reductive aminations, the title compound was obtained as an off-white solid: 1H NMR (400 MHz, DMSO-d6) δ ppm 0.48-0.59 (m, 2H) 0.59-0.69 (m, 2H) 1.40 (d, J=6.82 Hz, 3H) 2.51-2.56 (m, 4H) 2.75-2.82 (m, 1H) 3.19-3.29 (m, 4H) 3.48 (s, 2H) 4.70 (q, J=6.74 Hz, 1H) 6.92 (m, 4H) 7.32-7.37 (m, 1H) 7.41-7.46 (m, 2H) 7.51-7.57 (m, 2H) 7.69 (d, J=9.09 Hz, 2H) 8.13 (d, J=4.04 Hz, 1H) 10.71 (s, 1H). ESI-MS: m/z 497.3 (M+H)+. mp=217.0-223.5° C.