Benzamide, N-cyclopropyl-4-(1-piperazinyl)- → HCID 66716861, compound

Participants

Reaction Steps

Using 353A and N-cyclopropyl-4-(piperazin-1-yl)benzamide 284 in the general procedure for reductive aminations, the title compound was obtained as a light grey solid: 1H NMR (400 MHz, DMSO-d6) δ ppm 0.49-0.55 (m, 2H) 0.62-0.69 (m, 2H) 1.31 (d, J=6.82 Hz, 3H) 2.42-2.49 (m, 4H) 2.75-2.82 (m, 1H) 3.17-3.25 (m, 4H) 3.38 (s, 2H) 3.89 (s, 2H) 4.57 (q, J=6.74 Hz, 1H) 6.73-6.82 (m, 2 H) 6.91 (d, J=9.09 Hz, 2H) 7.14-7.19 (m, 1H) 7.19-7.24 (m, 2H) 7.24-7.30 (m, 2H) 7.69 (d, J=9.09 Hz, 2H) 8.14 (d, J=4.04 Hz, 1H) 10.60 (s, 1H). ESI-MS: m/z 511.4 (M+H)+. mp=192.3-203.2° C.

Provenance & Evidence