Ethyl 4-(4-oxopiperidin-1-yl)benzoate → Ethyl 4-(4-methylenepiperidin-1-yl)benzoate

Participants

Reaction Steps

Using ethyl 4-(4-oxopiperidin-1-yl)benzoate 390B (0.575 g, 2.325 mmol), Wittig olefination was carried out as described for 389A. The title compound was obtained as an off-white crystalline solid (0.338 g, 59.3% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.21-1.38 (m, 3H) 2.18-2.30 (m, 4H) 3.37-3.50 (m, 4H) 4.23 (q, J=7.16 Hz, 2H) 4.78 (s, 2H) 6.95-7.04 (m, 2H) 7.72-7.82 (m, 2H). ESI-MS: m/z 246.2 (M+H)+.

Provenance & Evidence