N-ethyl-4-fluorobenzamide → HCID 66716928, compound

Participants

Reaction Steps

Using N-ethyl-4-fluorobenzamide 281 as the alkylating agent, the reaction with 394E was carried out as described for 395 providing the title compound as a tan solid (0.0051 g, 6.0% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.10 (t, J=7.20 Hz, 3H) 1.40 (d, J=6.57 Hz, 3H) 1.59-1.74 (m, 2H) 1.92-2.07 (m, 1H) 3.08-3.34 (m, 3H) 3.54-3.69 (m, 2H) 4.36-4.50 (m, 1H) 4.58 (q, J=6.65 Hz, 1H) 6.50 (d, J=2.78 Hz, 1H) 6.52-6.63 (m, 1H) 6.88 (d, J=8.59 Hz, 1H) 6.92-7.04 (m, 2H) 7.72 (d, J=8.84 Hz, 2H) 8.18 (s, 1 H) 10.56 (s, 1H). ESI-MS: m/z 410.3 (M+H)+.

Provenance & Evidence