N-cyclopropyl-4-fluorobenzamide → HCID 66716834, compound

Participants

Reaction Steps

Using N-cyclopropyl-4-fluorobenzamide as the alkylating agent, the reaction with 394E was carried out as described for 395 providing the title compound as a tan solid (0.0308 g, 35.5% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 0.50-0.57 (m, 2H) 0.62-0.70 (m, 2H) 1.35-1.43 (m, 3H) 1.59-1.73 (m, 2H) 1.92-2.05 (m, 2 H) 2.80 (tq, J=7.34, 3.95 Hz, 1H) 3.11-3.22 (m, 2H) 3.56-3.69 (m, 2H) 4.38-4.49 (m, 1 H) 4.54-4.62 (m, 1H) 6.50 (d, J=2.78 Hz, 1H) 6.57 (dd, J=8.84, 2.78 Hz, 1H) 6.88 (d, J=8.84 Hz, 1H) 6.96 (d, J=9.09 Hz, 2H) 7.70 (d, J=8.84 Hz, 2H) 8.14 (d, J=4.29 Hz, 1H) 10.57 (s, 1H). ESI-MS: m/z 422.3 (M+H)+.

Provenance & Evidence