N-ethyl-3-methyl-4-(piperazin-1-yl)benzamide dihydrochloride → HCID 66716854, compound

Participants

Role	Name	HCID	Charge
Reactant	N-ethyl-3-methyl-4-(piperazin-1-yl)benzamide dihydrochloride	HCID 66926172	—
Reactant	8-Ethoxy-2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carbaldehyde	HCID 71813482	—
Product	HCID 66716854	HCID 66716854	—

Reaction Steps

Using 398B and N-ethyl-3-methyl-4-(piperazin-1-yl)benzamide-2HCl in the general procedure for reductive aminations, the title compound was obtained as a white solid: 1H NMR (400 MHz, DMSO-d6) δ ppm 1.09 (t, J=7.07 Hz, 3H) 1.32 (t, J=6.95 Hz, 3H) 1.40 (d, J=6.57 Hz, 3H) 2.26 (s, 3H) 2.51-2.59 (m, 4H) 2.88 (br. s., 4H) 3.19-3.29 (m, 2H) 3.42 (s, 2H) 3.98-4.09 (m, 2H) 4.55-4.64 (m, 1H) 6.51 (d, J=1.52 Hz, 1H) 6.63 (d, J=1.52 Hz, 1H) 7.02 (d, J=8.34 Hz, 1H) 7.55-7.69 (m, 2H) 8.26 (t, J=5.56 Hz, 1H) 10.57 (s, 1H). ESI-MS: m/z 467.4 (M+H)+. mp 199.8-199.9° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08669249B2
Source dataset	uspto-grants-2014_03
ORD ID	ord-b0d7a78468ea4f22adaf963120823f57
Source note	uspto-grants-2014_03