N-cyclopropyl-3-methyl-4-(piperazin-1-yl)benzamide dihydrochloride → HCID 66716876, compound

Participants

Reaction Steps

Using 398B and N-cyclopropyl-3-methyl-4-(piperazin-1-yl)benzamide-2HCl in the general procedure for reductive aminations, the title compound was obtained as a white solid: 1H NMR (400 MHz, DMSO-d6) δ ppm 0.51-0.57 (m, 2H) 0.63-0.70 (m, 2H) 1.33 (t, J=7.07 Hz, 3H) 1.41 (d, J=6.82 Hz, 3H) 2.25 (s, 3 H) 2.52-2.60 (m, 4H) 2.81 (td, J=7.26, 3.92 Hz, 1H) 2.89 (br. s., 4H) 3.42 (s, 2H) 3.98-4.10 (m, 2H) 4.54-4.66 (m, 1H) 6.51 (d, J=1.52 Hz, 1H) 6.63 (d, J=1.77 Hz, 1H) 7.01 (d, J=8.08 Hz, 1H) 7.55-7.66 (m, 2H) 8.23 (d, J=4.04 Hz, 1H) 10.57 (s, 1H). ESI-MS: m/z 479.5 (M+H)+. mp 223.4-223.5° C.

Provenance & Evidence