3-Chloro-N-ethyl-4-(piperazin-1-yl)benzamide → HCID 66717105, compound

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Reaction Steps

Using 403A and 3-chloro-N-ethyl-4-(piperazin-1-yl)benzamide 286 in the general procedure for reductive aminations, the title compound was obtained as a white solid: 1H NMR (400 MHz, DMSO-d6) δ ppm 1.10 (t, J=7.20 Hz, 3H) 1.39-1.46 (m, 3H) 2.52-2.61 (m, 4H) 3.05 (br. s., 4H) 3.21-3.30 (m, 2H) 3.45 (s, 2H) 4.70-4.78 (m, 1H) 6.78-6.83 (m, 2H) 7.13-7.21 (m, 2H) 7.77 (dd, J=8.59, 2.02 Hz, 1H) 7.87 (d, J=2.02 Hz, 1H) 8.43 (t, J=5.56 Hz, 1H) 10.81 (s, 1H). ESI-MS: m/z 509.3 (M+H)+. mp 101.7-104.0° C.

Provenance & Evidence