反应详情

Using 403A and N,3-dimethyl-4-(piperazin-1-yl)benzamide 298 in the general procedure for reductive aminations, the title compound was obtained as a white solid: 1H NMR (400 MHz, DMSO-d6) δ ppm 1.36-1.49 (m, 3H) 2.26 (s, 3H) 2.52-2.62 (m, 4H) 2.74 (d, J=4.55 Hz, 3H) 2.89 (br. s., 4H) 3.41-3.50 (m, 2H) 4.74 (q, J=6.65 Hz, 1H) 6.81 (s, 2H) 6.92-7.37 (m, 2H) 7.56-7.66 (m, 2H) 8.23 (d, J=4.55 Hz, 1H) 10.81 (s, 1H). ESI-MS: m/z 475.4 (M+H)+.