HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1184543Generated: November 2, 2026
(E)-3-(4-chloro-3-hydroxy-phenyl)-acrylic acid ethyl ester → HCID 21246560, compound
https://huagongshe.com/reaction/1184543
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | (E)-3-(4-chloro-3-hydroxy-phenyl)-acrylic acid ethyl ester | HCID 67337784 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 21246560 | HCID 21246560 | 96.8% |
Reaction Steps
(E)-3-(4-Chloro-3-hydroxy-phenyl)-acrylic acid ethyl ester (1.45 g, 6.4 mmol) was dissolved in a mixture of 6N HCl (8 ml) and acetic acid (8 ml) and heated at 85° C. for 3.5 hrs. Solvents were evaporated, giving 1.23 g of (E)-3-(4-chloro-3-hydroxy-phenyl)-acrylic acid as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08669261B2 |
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| Source dataset | uspto-grants-2014_03 |
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| ORD ID | ord-8943e8215094452b91b72658f739660a |
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| Source note | uspto-grants-2014_03 |
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