Water → HCID 71547804, compound

Participants

Reaction Steps

To a solution of Example 42 (30 mg, 0.078 mmol) in dimethyl sulfoxide (1 mL) was added sodium carbonate (8.24 mg, 0.078 mmol) and 2-iodopropane (13.22 mg, 0.078 mmol). The mixture was stirred at room temperature for 3 days. The mixture was poured into 10 mL water, and the crude product was extracted with dichloromethane (3×8 mL). The combined organic fractions were concentrated. The residue was purified by chromatography on silica gel (dichloromethane/methanol=10:1) to give the title compound. 1H NMR (500 MHz, DMSO-d6) δ ppm 0.91 (dd, 6H, J=7 Hz), 1.10 (m, 1H), 1.85 (m, 3H), 2.12 (m, 1H), 2.22 (m, 1H), 2.69 (m, 3H), 3.69 (m, 4H), 7.85 (m, 1H), 8.06 (m, 3H); MS (ESI) m/z 392 (M+H)+.

Provenance & Evidence