HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → [(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-2(1H)-yl][4-fluoro-3-(trifluoromethyl)phenyl]methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Fluoro-3-(trifluoromethyl)benzoyl Chloride | HCID 144253 | — |
| Reactant | (7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine | HCID 86680449 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | [(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]-pyrazin-2(1H)-yl][4-fluoro-3-(trifluoromethyl)phenyl]methanone | HCID 71547895 | — |
Reaction Steps
To a solution of Example 54F (47 mg, 0.18 mmol) and triethylamine (27 mg, 0.27 mmol) in dichloromethane (1 mL) was added 4-fluoro-3-(trifluoromethyl)benzoyl chloride (49 mg, 0.216 mmol). The mixture was stirred at room temperature for 3 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08669255B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-ed77c53ad7e24e8494074d46ec844ff0 |
| Source note | uspto-grants-2014_03 |