Triethylamine → HCID 71548072, compound

Participants

Reaction Steps

To a solution of Example 57 (50.7 mg, 0.2 mmol) and triethylamine (40 mg, 0.4 mmol) in dichloromethane (1 mL) was added 3-(trifluoromethyl)benzoyl chloride (50 mg, 0.24 mmol). The mixture was stirred at room temperature for 3 hours. The residue was purified by chromatography on silica gel (ethyl acetate) to give the title compound. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.70-1.92 (m, 2H), 2.16-2.27 (m, 3H), 2.52 (m, 1H), 2.82-3.25 (m, 2H), 3.60 (m, 2H), 4.45-4.62 (m, 1H), 5.28 (m, 1H), 6.83 (m, 1H), 7.75 (m, 5H), 8.20 (s, 1H); MS (ESI) m/z 426 (M+H)+.

Provenance & Evidence