反应详情

The compound obtained in Example 12-2 (351.3 mg) was dissolved in methanol (3.5 ml) and THF (3.5 ml). After the addition of 1 mol/l aqueous solution of sodium hydroxide (3.5 ml), the mixture was stirred for 2 hours at room temperature. After the reaction, the solvent was removed by distillation. The residue was dissolved in distilled water (1.2 ml) and aqueous solution of hydrochloric acid (1 mol/l) was added to adjust the pH to 4. The mixture was extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate. The solvent was removed by distillation to obtain the target compound (277.9 mg) as a white solid.

1. customAfter the reaction
2. customthe solvent was removed by distillation
3. dissolutionThe residue was dissolved in distilled water (1.2 ml)
4. additionaqueous solution of hydrochloric acid (1 mol/l) was added
5. extractionThe mixture was extracted with chloroform
6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
7. customThe solvent was removed by distillation